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We are a leading Exporter of exemptia injection, idrofos, idrofos 150 mg tabs, bandrone 150, bandrone and osteofos 70 from Nagpur, India.

Exemptia Injection

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Exemptia Injection
Approx. Rs 23,500 / Piece(s)
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With the assistance of vendor’s skilled professionals, we are engaged in providing high grade Exemptia Injection. Offered Exemptia injection is grouped within a class of medications called biologic response modifiers, or biologics. Our provided Exemptia injection is used for the treatment of moderate to severe rheumatoid arthritis (RA). This Exemptia injection suppresses the immune system, patients are at a greater risk for getting serious infections.

  • Highly effective
  • No bad effect
  • Purity

Other Details:

  • Exemptia 40 mg PFS is a prescription drug manufactured by Cadila (India)
  • It is used inIt is used for the treatment of moderate to severe rheumatoid arthritis (RA)
  • It is a biosimilar version of 40 mg also known as adalimumab
  • EXEMPTIATM is grouped within a class of medications called biologic response modifiers, or biologics
  • It works on the immune system, biologics block proteins that contribute to the disease process
  • Since EXEMPTIATM suppresses the immune system, patients are at a greater risk for getting serious infections.
  • Its considerably cheaper than the which is manufactured by Abbott & the company claims that it can be available to patients at upto 1/5 the cost of
In USD :- $350.


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  • Minimum Order Quantity: 5 Piece(s)
  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 25
  • Delivery Time: 10- 12 working days
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Idrofos

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Idrofos
Approx. Rs 2.6 / Pack
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IThis medication is a potent bisphosphonate, used in the prevention and treatment of osteoporosis in postmenopausal women. It increases bone mineral density and prevents the breakdown of bones.

Read more: Ibandronate (Boniva) Drug Information - Indications, Dosage, Side Effects and Precautions | Medindia Contraindicated to known hypersensitivity, patients with esophagus abnormalities, inability to stand or sit and decreased calcium level in blood.

Read more: Ibandronate (Boniva) Drug Information - Indications, Dosage, Side Effects and Precautions | Medindia Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Read more: Ibandronate (Boniva) Drug Information - Indications, Dosage, Side Effects and Precautions | Medindia comes as a tablet to take by mouth, without food

Read more: Ibandronate (Boniva) Drug Information - Indications, Dosage, Side Effects and Precautions | Medindia Caution should be exercised in patients with history of allergy, taking any oral medications, undergoing radiation therapy, anemia, gastrointestinal problems including esophageal ulcer, cancer, infectious diseases, blood clotting problem, liver or kidney disease, during pregnancy and breastfeeding.
It may cause pain in muscle and joints, if it so, consult with your doctor.
Avoid alcohol consumption while taking this medication.

Read more: Ibandronate (Boniva) Drug Information - Indications, Dosage, Side Effects and Precautions | Medindia


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  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Idrofos 150 Mg Tabs

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Idrofos 150 Mg Tabs
Approx. Rs 2.5 / Pack
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Fever; Influenza-Like Syndrome; Electrolyte Disturbances; GI Disturbances; Musculoskeletal Pain; Headache; Rash, Allergic Dermatitis; Anaemia; Decreased Alkaline Phosphatase; Hypercholesterolaemia; UTI; Local Reactions (Parenteral); Renal Impairment (Parenteral).Impaired Absorption With Aluminium, Calcium, Iron, Magnesium Compounds. Increased Risk Of GI Or Renal Adverse Effects With NSAIDs. Additive Hypocalcaemic Effects With Aminoglycosides.Severe Renal Impairment, Uncorrected Hypocalcaemia, Acute Upper GI Inflammation, Inability To Stand Or Sit Upright For At Least 60 Min (Oral).Ibandronic Acid Is A Potent Bone Resorption Inhibitor, Which Acts On Osteoclasts Or On Osteoclast Precursors. It Increases Bone Mineral Density By Reducing The Rate Of Bone Resorption. Absorption: Poorly Absorbed Orally. Absolute Bioavailability: <1%. Distribution: Protein-Binding: 85-99%. Excretion: Via Urine. Unabsorbed Drug Via Faeces


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  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Bandrone 150

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Bandrone 150
Approx. Rs 1.9 / Pack
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Fever; Influenza-Like Syndrome; Electrolyte Disturbances; GI Disturbances; Musculoskeletal Pain; Headache; Rash, Allergic Dermatitis; Anaemia; Decreased Alkaline Phosphatase; Hypercholesterolaemia; UTI; Local Reactions (Parenteral); Renal Impairment (Parenteral).Impaired Absorption With Aluminium, Calcium, Iron, Magnesium Compounds. Increased Risk Of GI Or Renal Adverse Effects With NSAIDs. Additive Hypocalcaemic Effects With Aminoglycosides.Severe Renal Impairment, Uncorrected Hypocalcaemia, Acute Upper GI Inflammation, Inability To Stand Or Sit Upright For At Least 60 Min (Oral).Ibandronic Acid Is A Potent Bone Resorption Inhibitor, Which Acts On Osteoclasts Or On Osteoclast Precursors. It Increases Bone Mineral Density By Reducing The Rate Of Bone Resorption. Absorption: Poorly Absorbed Orally. Absolute Bioavailability: <1%. Distribution: Protein-Binding: 85-99%. Excretion: Via Urine. Unabsorbed Drug Via Faeces.History Of Bone/Joint/Muscle Pain; Dysphagia, Oesophageal Disease, Gastritis, Duodenitis, Ulcers. Risk Factors For Osteonecrosis Of The Jaw. Pregnancy And Lactation.


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  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Bandrone

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Bandrone
Approx. Rs 2.6 / Pack
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Fever; Influenza-Like Syndrome; Electrolyte Disturbances; GI Disturbances; Musculoskeletal Pain; Headache; Rash, Allergic Dermatitis; Anaemia; Decreased Alkaline Phosphatase; Hypercholesterolaemia; UTI; Local Reactions (Parenteral); Renal Impairment (Parenteral).Impaired Absorption With Aluminium, Calcium, Iron, Magnesium Compounds. Increased Risk Of GI Or Renal Adverse Effects With NSAIDs. Additive Hypocalcaemic Effects With Aminoglycosides.Severe Renal Impairment, Uncorrected Hypocalcaemia, Acute Upper GI Inflammation, Inability To Stand Or Sit Upright For At Least 60 Min (Oral).Ibandronic Acid Is A Potent Bone Resorption Inhibitor, Which Acts On Osteoclasts Or On Osteoclast Precursors. It Increases Bone Mineral Density By Reducing The Rate Of Bone Resorption. Absorption: Poorly Absorbed Orally. Absolute Bioavailability: <1%. Distribution: Protein-Binding: 85-99%. Excretion: Via Urine. Unabsorbed Drug Via Faeces.History Of Bone/Joint/Muscle Pain; Dysphagia, Oesophageal Disease, Gastritis, Duodenitis, Ulcers. Risk Factors For Osteonecrosis Of The Jaw. Pregnancy And Lactation.


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  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Osteofos 70

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Osteofos 70
Approx. Rs 2.6 / Pack
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Osteofos tablets 70mg are used to treat osteoporosis, to reduce the risk of vertebral and hip fractures in men and postmenopausal women, and to prevent osteoporosis developing in postmenopausal women who are at risk. Osteoporosis is the loss of bone mass resulting in brittle bones which can fracture more easily and is often associated with lack of oestrogen in postmenopausal women or following treatment with a corticosteroid, an anti-inflammatory steroid that can cause bone loss. Osteofos tablets 70mg are also used to treat Paget's disease of bone in men and women, in which the normal mechanism of bone turnover is faulty and bone structure becomes abnormal causing weakness. Osteofos tablets 70mg help to strengthen the bone structure making them less likely to fracture. Osteofos tablets 70mg contain alendronate, which is a bisphosphonate; a synthetic chemical similar to the naturally occurring mineral in bone called pyrophosphate that mediates bone turnover, a normal part of bone remodelling, which is a dynamic process that allows bones to grow and repair. acts directly on bone and binds to hydroxyapatite (the scaffolding of bone architecture), specifically at the site of bone resorption (the process for removal of old bone tissue), and inhibits the action of bone cells called osteoclasts that are responsible for bone resorption. has no effect on osteoblast cells that are responsible for bone formation (laying down of new bone tissue). Osteofos tablets 70mg change the balance of bone turnover so that bone breakdown is reduced relative to bone building, which increases bone mass, making bones stronger and more resistant to fracture, which can be painful and cause loss of height if the fracture occurs in the spine. Although in Osteofos tablets 70mg begin working on bone turnover immediately, it may take several months before measurable effects on bone mass may be seen. Osteofos tablets 70mg contain sodium trihydrate. Osteofos tablets are available from Inhouse Pharmacy in 2 doses:
  • Osteofos 70mg tablets for once weekly administration
  • Osteofos 10mg tablets for once daily administration


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  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Ibandronic Acid

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Ibandronic Acid
Approx. Rs 2.9 / Pack
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Ibandronic acid is a type of bisphosphonate. It is also called Bondronat. Doctors use it to try to prevent bone problems in people whose cancer has weakened the bone. It is most commonly used to treat breast cancer that has spread to the bone (secondary breast cancer).

You may also have ibandronic acid to treat high levels of calcium in the blood (hypercalcaemia) caused by secondary bone cancer.You should take the tablet once each day with a full glass of water. Swallow it whole and do not crush, suck or chew it. You need to take the tablet on an empty stomach at least 6 hours after food. So the best time is first thing in the morning before breakfast and before any other medicines or supplements. Take it while you are standing or sitting upright. After taking the tablet do not eat or drink anything (except for water) for at least 30 minutes. You should stay sitting or standing for an hour.

It is very important that you take tablets according to the instructions your doctor or pharmacist gives you. For example, whether you have a full or empty stomach can affect how much of a drug gets into your bloodstream. You should take the right dose, not more or less. And never stop taking a cancer drug without talking to your specialist first.Ibandronic acid can go into your bloodstream as a drip (infusion). You have the drip through a fine tube (cannula) in your arm, a central line, a portacath or a PICC line.

You have the drip either

  • For 1 to 2 hours, as a one off treatment to lower the calcium levels in your blood, or
  • For 15 minutes, every 3 to 4 weeks as a treatment to prevent or reduce bone damageFor ibandronic acid to work well you need to have good levels of vitamin D and calcium in your body. If you cannot take in enough vitamin D and calcium in your diet, your doctor will prescribe vitamin D and calcium supplements for you.You have blood tests before starting treatment and regularly during your treatment. The tests check the level of calcium in your blood. They also check how well your liver and kidneys are working.


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  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Osteoporosis Medicines

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Osteoporosis Medicines
Approx. Rs 2.6 / Pack
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When it's time to choose an osteoporosis medicine, you have lots of options. In the past 10 years, science has come a long way in helping women treat their bone problems.Make sure you're getting adequate calcium and vitamin D, advises Eve Scopelitis, MD, an internist with Ochsner Medical Center in New Orleans. "Vitamin D is now being recognized as a key player inosteoporosis. Even though patients are taking calcium plus D, they may not be getting enough D. They may need prescription vitamin D -- it's that important.In fact, even when you start taking osteoporosis medicine, it's critical to keep getting these supplements, says Holly Thacker, MD, director of the Women's Health Center at The Cleveland Clinic. "A postmenopausal woman needs 1,500 milligrams calcium daily, plus 1,000 units of vitamin D. Some need prescription-strength vitamin D [Calcitriol]. This deficiency is a serious problem."Talk to your doctor about getting a bone resorption marker test -- a blood or urine test, advises Mary Ruppe, MD, an endocrinologist with the University of Texas Health Science Center in Houston.

Bone resportion is bone loss -- and the test will tell you whether yourosteoporosis medicine is having an effect on bone loss, she explains. "The first test is your baseline. Get it before you start the medication. Then get it checked after you've taken the drug for a few months to see the change." Insurance typically covers two tests the first year.

Now let's weigh the advantages and disadvantages of six main types of osteoporosis medicine.



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  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Idrofos Injection

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Idrofos Injection
Approx. Rs 1.9 / Pack
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Idrofos-3 Inj. Fever; Influenza-Like Syndrome; Electrolyte Disturbances; GI Disturbances; Musculoskeletal Pain; Headache; Rash, Allergic Dermatitis; Anaemia; Decreased Alkaline Phosphatase; Hypercholesterolaemia; UTI; Local Reactions (Parenteral); Renal Impairment (Parenteral).Impaired Absorption With Aluminium, Calcium, Iron, Magnesium Compounds. Increased Risk Of GI Or Renal Adverse Effects With NSAIDs. Additive Hypocalcaemic Effects With Aminoglycosides.Severe Renal Impairment, Uncorrected Hypocalcaemia, Acute Upper GI Inflammation, Inability To Stand Or Sit Upright For At Least 60 Min (Oral).Ibandronic Acid Is A Potent Bone Resorption Inhibitor, Which Acts On Osteoclasts Or On Osteoclast Precursors. It Increases Bone Mineral Density By Reducing The Rate Of Bone Resorption. Absorption: Poorly Absorbed Orally. Absolute Bioavailability: <1%. Distribution: Protein-Binding: 85-99%. Excretion: Via Urine. Unabsorbed Drug Via Faeces.History Of Bone/Joint/Muscle Pain; Dysphagia, Oesophageal Disease, Gastritis, Duodenitis, Ulcers. Risk Factors For Osteonecrosis Of The Jaw. Pregnancy And Lactation.


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  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Bandrone Injection

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Bandrone Injection
Approx. Rs 2 / Pack
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If you’re a woman diagnosed with osteoporosis, you know treatment is important. But you may be like other women who have difficulty taking tablets. Non-oral Bandrone Injection may be just the right treatment for you.Bandrone Injection—administered by a healthcare professional just four times a year—does not have the same dosing guidelines of an oral bisphosphonate, which require taking the pill with plain water on an empty stomach upon rising in the morning, and remaining upright and avoiding food, drink (except plain water) and other medications for at least 30 minutes after taking the pill. Just one Bandrone Injection treatment every three months, provides continuous bone protection because it binds with and stays in your bones. Visit your doctor’s office.A healthcare professional will give you your BandroneInjection. Do not administer Bandrone Injection to yourself.The injection itself takes about 30 seconds.Your healthcare professional will check your kidneys before giving each injection.After that, you’re set for the next 3 months. You don’t have to worry about taking it on an empty stomach or staying upright.Bandrone Injection is from the makers of Bandrone Tablets so you get the same Bandrone protection for your bones that people who take the oral treatment receive. Like the tablet, Bandrone Injection not only maintains bone density, it actually builds your bones to help reduce fractures. With Bandrone Injection, you can feel confident your osteoporosis is being treated effectively. BONIVA Injection is a prescription medicine used to treat postmenopausal osteoporosis.BONIVA Injection must be administered intravenously (IV) only by a healthcare professional. Do NOT administer BONIVA Injection to yourself. Patients with severe kidney problems or who are allergic to BONIVA should not receive BONIVA Injection. You should have a blood test to check your kidneys prior to each injection of BONIVA. Your doctor must correct low blood calcium and vitamin D levels before starting BONIVA Injection therapy. You must also take calcium and vitamin D supplements while receiving BONIVA Injection therapy. Side effects are usually mild and of brief duration. The most common side effects with BONIVA Injection are bone, muscle, or joint pains, flu-like symptoms, and headache. Flu-like symptoms usually occur only after the first injection of BONIVA. Tell your doctor and dentist about all the medicines you take. Tell them if you develop jaw problems (especially following a dental procedure) or severe bone, joint, and/or muscle pain


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  • Pay Mode Terms: T/T (Bank Transfer)
  • Port of Dispatch: Mumbai
  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Risofos 70 Tablets

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Risofos 70 Tablets
Approx. Rs 1.98 / Pack
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Brand Name:Risofos
Generic Name:Risedronate
Form:Tablets
Manufacturer:Cipla

Risofos is used to treat and prevent osteoporosis in woman who have undergone menopause or patients who are taking glucocorticoids. The active ingredient risedronate is considered a bisphosphonates type of medication. The medication works by slowing bone loss to help maintain strong bones and reduce the risk of fractures. Some patients may also use the medication to treat Pagets disease of bone.Risofos should be taken orally once per week or as directed by a doctor. The tablets should be taken with a full glass of water in the morning before consuming breakfast. The medication should always be taken with plain water and not mineral water, dairy products or juice as it may interfere with the absorption of the drug. Contact a doctor for the correct dosage as it will depend on the condition being treated and the patients response to the medication. The tablets should be swallowed whole and not split, crushed, chewed or held in the mouth for any length of time.Risofos may cause unwanted side effects such as:
  • Joint pain
  • Dizziness
  • Headaches
  • Constipation
  • Diarrhea
  • Flu symptoms
  • Upset stomach

Contact a doctor immediately should side effects persist or encounter more severe side effects such as:

  • Loosening of teeth
  • Pain in thigh, hip or groin
  • Jaw pain, numbness or swelling
  • Worsening heartburn
  • Difficult breathing or swallowing
  • Chest painImmediately proceed to your nearest emergency department if you suffer an allergic reaction. Symptoms usually associated with such a reaction include difficulty breathing or swallowing, chest tightness, swelling, skin rashes, and hives.

    Risofos is not always suitable for all patients. Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding, trying to conceive, using any other medication (prescription or non-prescription), using any herbal products or supplements, or if you have any allergies or other health problems.

    The correct dosage and prescription commonly depend on the patient and the condition being treated. Do not adjust your dosage without the approval of your health care provider. This product is only for use as prescribed and instructed.



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  • Production Capacity: 10000
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Rheumatoid Arthritis

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Rheumatoid Arthritis
Approx. Rs 1.98 / Pack
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heumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Autoimmune diseases are illnesses that occur when the body's tissues are mistakenly attacked by their own immune system. The immune system contains a complex organization of cells and antibodies designed normally to "seek and destroy" invaders of the body, particularly infections. Patients with autoimmune diseases have antibodies and immune cells in their blood that target their own body tissues, where they can be associated with inflammation. While inflammation of the tissue around the joints and inflammatory arthritis are characteristic features of rheumatoid arthritis, the disease can also cause inflammation and injury in other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. Rheumatoid arthritis that begins in people under 16 years of age is referred to as juvenile idiopathic arthritisWhile rheumatoid arthritis is a chronic illness, meaning it can last for years, patients may experience long periods without symptoms. However, rheumatoid arthritis is typically a progressive illness that has the potential to cause significant joint destruction and functional disability.

A joint is where two bones meet to allow movement of body parts. Arthritis means joint inflammation. The joint inflammation of rheumatoid arthritis causes swelling, pain, stiffness, and redness in the joints. The inflammation of rheumatoid disease can also occur in tissues around the joints, such as the tendons, ligaments, and muscles.

In some people with rheumatoid arthritis, chronic inflammation leads to the destruction of the cartilage, bone, and ligaments, causing deformity of the joints. Damage to the joints can occur early in the disease and be progressive. Moreover, studies have shown that the progressive damage to the joints does not necessarily correlate with the degree of pain, stiffness, or swelling present in the joints.heumatoid arthritis is a common rheumatic disease, affecting approximately 1.3 million people in the United States, according to current census data. The disease is three times more common in women as in men. It afflicts people of all races equally. The disease can begin at any age and even affects children (juvenile idiopathic arthritis), but it most often starts after 40 years of age and before 60 years of age. Though uncommon, in some families, multiple members can be affected, suggesting a genetic basis for the disorder. Continue Reading


 



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  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Arthritic Drugs

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Arthritic Drugs
Approx. Rs 1.23 / Pack
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The Arthritis Today Drug Guide provides information about the many drugs used to treat arthritis and arthritis-related conditions. The guide gives you the must-know facts – details on dosages, side effects and warnings – that leading experts in rheumatology want you to know about.

For a customized experience: Try My MedTracker. It allows you to keep track of the medications you take, your dosages and more. Add entries with one click from the Drug Guide pages.The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

Rheumatoid arthritis (RA) is the second most common type of arthritis. It affects about 1.5 millionAmericans. Unlike osteoarthritis (OA), RA is an inflammatory disease that’s caused by an autoimmune condition. In RA, your own body attacks healthy joint tissues, which results in redness, swelling (inflammation), and pain.

RA treatment options are numerous. There are two main goals of RA medication therapy: to block inflammation, and thus prevent the body from damaging the joints.



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  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Osteoarthritis Medicines

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Osteoarthritis Medicines
Approx. Rs 2.6 / Pack
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  • Analgesics. These are pain relievers and include acetaminophen, (narcotics) and an atypical called . They are available over-the-counter or by prescription.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs). These are the most commonly used drugs to ease inflammation and related pain
  • Medicine doesn't cure arthritis or slow the time it takes for cartilageto break down. But it can help reduce pain and stiffness, which can make it easier for you to move.
  • Medicine should be used along with other treatments, such asexercise and physical therapy, to help keep your joints working and moving well.
  • If you have certain health problems, you may not be able to take some kinds of pain medicine. Be sure to tell your doctor if you have a history of bleeding in your stomach or another part of your digestive tract. And tell your doctor if you have a stomach ulcer, kidneyproblems, or heart failure, or if you take a blood-thinner medicineMedicines that work for some people don't work for others. Be sure to let your doctor know if the medicine you're taking doesn't help. You may need to try several kinds of medicines to find one that works for you.


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  • Production Capacity: 10000
  • Delivery Time: 10- 12 working Days
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Diacerein

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Diacerein
Approx. Rs 2.5 / Pack
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Diacerein, also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis. It works by inhibiting interleukin-1 beta. Wikipedia Pain may improve slightly more in people taking diacerein.

Improvement in physical function is about the same for people taking diacerein, or a placebo (fake pill). This may have happened by chance.

Diacerein may slow the process of joint space narrowing slightly of the hip but may have little or no difference on the knee joint as it is seen on an xray.

Diacerein may cause side effects in the lower digestive tract, such as diarrhoea.

Further research is very likely to have an important impact on our confidence in these findings and is likely to change the estimates.People who took diacerein rated their pain to be 9 points lower on a scale of 0 (no pain) to 100 (extreme pain) after taking the medication for three to 36 months (9% absolute improvement).

People who took diacerein rated their pain to be 34 on a scale of 0 to 100 after taking the medication compared to people who took a fake pill and rated their pain to be 43 points on a scale of 0 to 100.

Physical function after two to 36 months (lower score means worse function)

People who took diacerein rated their physical function to be 0.30 points lower on a scale of 0 to 24 after taking the medication for two to 36 months (0% absolute improvement).

People who took diacerein rated their physical function to be 9.3 on a scale of 0 to 24 after taking the medication compared to people who took a fake pill and rated their physical function to be 9 points on a scale of 0 to 24.Seven more people who took placebo had radiographic progression (absolute difference of 7%).

42 of every 100 people who took diacerein experienced reduction in joint space narrowing of at least 0.5 mm compared to 49 of every 100 people who took a fake pill.

Quality of life

The review authors found no studies about quality of life of people who took diacerein compared with placebo.

There was no difference in quality of life of people who took diacerein compared with nonsteroidal antiinflammatory drugs (NSAIDs). This may have happened by chance.



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  • Production Capacity: 10000
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Lornoxicam

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Lornoxicam
Approx. Rs 2.6 / Pack
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LornoxicamLornoxicam is a nonsteroidal antiinflammatory drug (NSAID) that is used as a painkiller (analgesic). A high level of pain relief is experienced by about 45% of those with moderate to severe postoperative dental pain after a single dose of lornoxicam 8 mg, compared to about 10% with placebo. This is comparable to the proportion experiencing the same level of pain relief with to 400 mg. Adverse events were generally mild and did not differ from placebo in these singe dose studies. There were insufficient data to assess duration of action, but it is likely to be similar to 200 mg.Background: Lornoxicam is one of the oxicam class of nonsteroidal antiinflammatory drugs (NSAIDs), producing analgesic and antipyretic effects in part through the nonselective inhibition of cyclooxygenase1 and 2. It is prescribed for osteoarthritis,rheumatoid arthritis, acute lumbarsciatica conditions and for postoperative pain management. Lornoxicam is available in 31 countries in Europe, the Middle East, Far East and South America, and is becoming more widely available.

Objectives: To assess the efficacy, the time to onset of analgesia, the time to use of rescue medication and any associated adverse events of single dose oral lornoxicam in acute postoperative pain.

Search methods: We searched CENTRAL, MEDLINE, EMBASE and PubMed to June 2009.

Selection criteria: Single oral dose, randomised, doubleblind, placebocontrolled trials of lornoxicam for relief of established moderate to severe postoperative pain in adults.

Data collection and analysis: Studies were assessed for methodological quality and the data extracted by two review authors independently. Summed total pain relief over 6 hours (TOTPAR 6) was used to calculate the number of participants achieving at least 50% pain relief. These derived results were used to calculate, with 95% confidence intervals (CIs), the relative benefit compared to placebo, and the number needed to treat (NNT) for one participant to experience at least 50% pain relief over 6 hours. Numbers of participants using rescue medication over specified time periods, and time to use of rescue medication, were sought as additional measures of efficacy. Information on adverse events and withdrawals was collected. Three studies, with 628 participants, met the inclusion criteria; 434 participants were treated with various doses (2 mg to 32 mg) of lornoxicam, 118 with placebo, and 76 with other active therapies. All the participants had pain following third molar extraction, and study duration was 8 to 24 hours. The NNT for at least 50% pain relief over 6 hours after a single dose of lornoxicam 8 mg was 2.9 (2.3 to 4.0). There were insufficient data to analyse other doses or use of rescue medication. No serious adverse events or withdrawals were reported by any of the studies.

Authors' conclusions: Oral lornoxicam is effective at treating moderate to severe acute postoperative pain, based on limited data. Adverse events did not differ significantly from placebo.

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group.



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Alfacalcidol

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Alfacalcidol
Approx. Rs 1.6 / Pack
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Alfacalcidol is an analogue of vitamin D used for supplementation in humans and as a poultry feed Alfacalcidol is indicated in all conditions where there is a disturbance of calcium metabolism due to impaired 1-α hydroxylation such as when there is reduced renal function. The main indications are:

a) Renal osteodystrophy

b) Hyperparathyroidism (with bone disease)

c) Hypoparathyroidism

d) Neonatal hypocalcaemia

e) Nutritional and malabsorptive rickets and osteomalacia

f) Pseudo-deficiency (D-dependent) rickets and osteomalacia

g) Hypophosphataemic vitamin D resistant rickets and osteomalaciaRoute of administration: oral

The capsules should be swallowed whole with a drink of water.

Initial dose for all indications:

Adults: 1 microgram/day

Dosage in the elderly: 0.5 microgram/day

Neonates and premature infants: 0.05 – 0.1 microgram/kg/day

Children under 20kg bodyweight: 0.05 microgram/kg/day

Children over 20kg bodyweight: 1 microgram/day

The dose of Alfacalcidol should be adjusted thereafter to avoid hypercalcaemia according to the biochemical response. Indices of response include plasma levels of calcium (ideally corrected for protein binding), alkaline phosphatase, parathyroid hormone, as well as radiographic and histological investigations.

Plasma levels should initially be measured at weekly intervals. The daily dose of Alfacalcidol may be increased by increments of 0.25 – 0.5 microgram. When the dose is stabilised, measurements may be taken every 2 – 4 weeks.Most adult patients respond to doses between 1 and 3 micrograms per day. When there is biochemical or radiographic evidence of bone healing, (and in hypoparathyroid patients when normal plasma calcium levels have been attained), the dose generally decreases. Maintenance doses are generally in the range of 0.25 to 1 microgram per day. If hypercalcaemia occurs, Alfacalcidol should be stopped until plasma calcium returns to normal (approximately 1 week) then restarted at half the previous dose.

a) Renal bone disease:

Patients with relatively high initial plasma calcium levels may have autonomous hyperparathyroidism, often unresponsive to Alfacalcidol. Other therapeutic measures may be indicated.

Before and during treatment with Alfacalcidol, phosphate binding agents should be considered to prevent hyperphosphataemia. It is particularly important to make frequent plasma calcium measurements in patients with chronic renal failure because prolonged hypercalcaemia may aggravate the decline of renal function.



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